Gene polymorphisms of Patatin-like phospholipase domain containing 3 (PNPLA3), adiponectin, leptin in diabetic obese patients
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چکیده
منابع مشابه
Association between patatin-like phospholipase domain-containing 3 gene (PNPLA3) polymorphism and overweight/obesity: a meta-analysis
Background: The patatin-like phospholipase domain-containing 3 (PNPLA3, rs738409) gene polymorphism has been implicated in susceptibility to overweight and obesity, but study results are still controversial. Objective: The present meta-analysis was performed to evaluate the relationship between PNPLA3 polymorphism and overweight/obesity among adults, children or adolescents. Methods: A literatu...
متن کاملAssociation Between Patatin-Like Phospholipase Domain Containing 3 Gene (PNPLA3) Polymorphisms and Nonalcoholic Fatty Liver Disease: A HuGE Review and Meta-Analysis
We conducted a meta-analysis to assess the association between patatin-like phospholipase domain-containing 3 (PNPLA3) rs738409 polymorphism and nonalcoholic fatty liver disease (NAFLD) and its subtypes simple steatosis(SS) and nonalcoholic steatohepatitis (NASH). The study-specific odds ratios (ORs) and 95% confidence intervals (CIs) were calculated using fixed-effects or random-effects models...
متن کاملcorrelation between patatin-like phospholipase domain-containing protein 3 gene polymorphisms and liver cirrhosis in a chinese han population with chronic hepatitis b
results the allele and genotype distributions of pnpla3 rs738409 and rs2281135 were not significantly different between the chb and lc groups. after segregation on the basis of sex, no significant correlation between pnpla3 (rs738409 and rs2281135) genotypes/alleles and liver cirrhosis was detected. moreover, none of the haplotypes in pnpla3 (rs738409 and rs2281135) was found to be statisticall...
متن کاملAssociation of patatin-like phospholipase domain-containing protein 3 gene polymorphisms with susceptibility of nonalcoholic fatty liver disease in a Han Chinese population
Gene polymorphisms had been found to be associated with increased risk of nonalcoholic fatty liver disease (NAFLD). The aim of the present study was to assess the association between rs2896019 and rs3810622 in PNPLA3 with the susceptibility to NAFLD in Han Chinese population.A total of 384 NAFLD patients and 384 controls were enrolled in the study. Blood samples collected from each subject were...
متن کاملa meta-analysis of the association between the i148m variant of patatin-like phospholipase domain containing 3 gene and the presence of chronic hepatitis c
conclusions the current meta-analysis showed an association between frequency of gg genotype of pnpla3 and the risk of development of chc in various populations throughout the world. results five hospital-based case-control studies were included in the final analysis. the overall frequency of pnpla3 gene polymorphisms was 20.4% (205/1005) in chc and 10.23% (53/518) in controls. the summary odds...
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ژورنال
عنوان ژورنال: PLOS ONE
سال: 2020
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0234465